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KMID : 1199120100340050320
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Korean Diabetes Journal
2010 Volume.34 No. 5 p.320 ~ p.326
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ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus
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Jeong Dae-Joon
Lee Dong-Gyu
Kim Hee-Jung
Cho Eun-Hee
Kim Sang-Wook
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Abstract
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Background:Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized calcification in infancy and an increased risk of developing type 2 diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be associated with increased coronary artery calcification in T2DM patients.
Methods:The study subjects were aged 34 to 85 years and showed no evidence of clinical cardiovascular disease prior to recruitment. A total of 140 patients with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 K121Q polymorphisms were identified.
Results:The prevalence of subjects carrying the KQ genotype was 12.9% (n = 18). There were no 121QQ homozygotes. Patients with the KQ genotype did not show a significantly higher CAC score (122 vs. 18; P = 0.858). We matched each patient with the KQ genotype to a respective control with the KK genotype by gender, age, and duration of diabetes. When compared to matched controls, we observed no significant difference in CAC score (P = 0.959).
Conclusions:The ENPP1 K121Q polymorphism does not appear to be associated with coronary artery calcification in patients with T2DM.
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KEYWORD
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Coronary artery calcification, Diabetes mellitus, type 2, Ectonucleotide pyrophosphatase phosphodiesterase 1
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